Chee-Onn Leong Selected Research

2- (3,4- dimethoxyphenyl)- 5- fluorobenzothiazole

11/2015	Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery.
10/2011	CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells.

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Chee-Onn Leong Research Topics

Disease

34	Neoplasms (Cancer) 05/2022 - 10/2006
14	Breast Neoplasms (Breast Cancer) 01/2021 - 05/2007
5	Pancreatic Neoplasms (Pancreatic Cancer) 05/2022 - 04/2019
5	Nasopharyngeal Carcinoma 01/2022 - 01/2012
4	Carcinogenesis 01/2022 - 12/2013
3	Neoplasm Metastasis (Metastasis) 02/2020 - 09/2012
3	Colorectal Neoplasms (Colorectal Cancer) 01/2017 - 10/2011
3	Carcinoma (Carcinomatosis) 11/2015 - 09/2010
2	Squamous Cell Carcinoma of Head and Neck 07/2021 - 12/2020
2	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 10/2020
2	Adenocarcinoma 09/2019 - 01/2018
2	Triple Negative Breast Neoplasms 09/2012 - 03/2010
1	Influenza in Birds (Avian Flu) 01/2022
1	Fibroadenoma 06/2021
1	Nasopharyngeal Neoplasms (Cancer of the Nasopharynx) 04/2021
1	Virus Diseases (Viral Diseases) 04/2021
1	Inflammation (Inflammations) 04/2021
1	Melanoma (Melanoma, Malignant) 02/2021
1	Neutropenia 01/2021
1	Genomic Instability 01/2019
1	Necrosis 01/2017
1	Aneuploidy (Aneuploid) 10/2014

Drug/Important Bio-Agent (IBA)

9	Cisplatin (Platino)FDA LinkGeneric 07/2021 - 05/2007
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2010
4	Biomarkers (Surrogate Marker)IBA 06/2021 - 03/2010
3	Biological ProductsIBA 09/2021 - 10/2014
3	Small Interfering RNA (siRNA)IBA 09/2021 - 09/2016
3	Protein Isoforms (Isoforms)IBA 01/2021 - 05/2007
3	Progesterone Receptors (Progesterone Receptor)IBA 09/2012 - 05/2007
2	Histone Deacetylase InhibitorsIBA 05/2022 - 02/2020
2	Histone Deacetylases (Histone Deacetylase)IBA 05/2022 - 02/2020
2	Mitochondrial DNA (mtDNA)IBA 07/2021 - 12/2020
2	sphingosine kinaseIBA 01/2021 - 01/2020
2	AlkaloidsIBA 01/2021 - 10/2014
2	Phosphatidylinositols (Phosphatidylinositol)IBA 10/2020 - 01/2017
2	Doxorubicin (Adriamycin)FDA LinkGeneric 02/2020 - 09/2016
2	Gemcitabine FDA Link 09/2019 - 01/2018
2	Pharmaceutical PreparationsIBA 01/2018 - 10/2014
2	jerantinine AIBA 01/2017 - 10/2014
2	ProdrugsIBA 01/2017 - 11/2015
2	TubulinIBA 01/2017 - 10/2014
2	2- (3,4- dimethoxyphenyl)- 5- fluorobenzothiazoleIBA 11/2015 - 10/2011
2	Estrogen ReceptorsIBA 09/2012 - 10/2007
2	Estrogens (Estrogen)FDA Link 03/2010 - 05/2007
1	p38 Mitogen-Activated Protein KinasesIBA 01/2022
1	Hemagglutinins (Hemagglutinin)IBA 01/2022
1	Biocompatible Materials (Biomaterials)IBA 09/2021
1	Messenger RNA (mRNA)IBA 06/2021
1	CytokinesIBA 04/2021
1	InflammasomesIBA 04/2021
1	TocotrienolsIBA 02/2021
1	Janus Kinase 1IBA 01/2021
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2021
1	Docetaxel (Taxotere)FDA Link 01/2021
1	serum-glucocorticoid regulated kinaseIBA 10/2020
1	Phenobarbital (Luminal)FDA Link 02/2020
1	quisinostatIBA 02/2020
1	thiazolyl blueIBA 09/2019
1	Immune Checkpoint InhibitorsIBA 01/2019
1	compound 20IBA 01/2019
1	Immune Checkpoint ProteinsIBA 01/2019
1	SirtuinsIBA 01/2018
1	cudraflavone CIBA 01/2017
1	DNA VaccinesIBA 01/2017
1	Nucleosomes (Nucleosome)IBA 01/2017
1	CaspasesIBA 01/2017
1	asparaginylendopeptidase (legumain)IBA 01/2017
1	Caspase 3 (Caspase-3)IBA 01/2017
1	Indole AlkaloidsIBA 01/2017
1	RNA Splicing FactorsIBA 01/2017
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 09/2016
1	Type 4 Fibroblast Growth Factor ReceptorIBA 09/2016
1	LigandsIBA 09/2016
1	Peptides (Polypeptides)IBA 01/2016
1	Mixed Function Oxygenases (Monooxygenases)IBA 01/2016
1	EnzymesIBA 01/2016
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2016
1	Cytochrome P450 Family 2IBA 01/2016
1	DNA AdductsIBA 11/2015
1	Adenosine Triphosphate (ATP)IBA 10/2015
1	Fluorouracil (Carac)FDA LinkGeneric 10/2015
1	Epirubicin (Ellence)FDA LinkGeneric 10/2015
1	4- hydroxy- 3- (4- (2- hydroxyphenyl)phenyl)- 6- oxo- 7H- thieno(2,3- b)pyridine- 5- carbonitrileIBA 10/2015
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/2015
1	nutlin 3IBA 10/2015
1	Metformin (Glucophage)FDA LinkGeneric 10/2015
1	AICA ribonucleotide (ZMP)IBA 10/2015
1	Vinca AlkaloidsIBA 10/2014
1	Vincristine (Oncovin)FDA LinkGeneric 10/2014
1	Taxoids (Taxanes)IBA 10/2014
1	Cyclin B1IBA 10/2014

Therapy/Procedure

13	Therapeutics 09/2021 - 07/2011
7	Drug Therapy (Chemotherapy) 07/2020 - 09/2010
4	Immunotherapy 05/2022 - 01/2019
3	Radiotherapy 07/2020 - 01/2020
1	Immunomodulation 05/2022
1	Drug Tapering 01/2021
1	Castration 01/2021
1	Combination Drug Therapy (Combination Chemotherapy) 10/2015
1	Aftercare (After-Treatment) 10/2014